Pharmacokinetic Behaviour of Enrofloxacin after Single Intramuscular Dosage in American Black Vultures (Coragyps atratus)

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چکیده

The aim of the study was to investigate intramuscular pharmacokinetics enrofloxacin in black vultures (Coragyps atratus). a single dose (10 mg/kg) studied six vultures. Plasma concentrations and its active metabolite, ciprofloxacin, were determined by high-performance liquid chromatography (HPLCuv). Pharmacokinetic parameters estimated using non-compartmental compartmental analysis. After administration, showed rapid complete absorption, reaching Cmax value 3.26 ± 0.23 ?g/mL at 1.75 0.53 h. A long terminal half-life 19.58 h has been observed. Using previously published MIC values perform PK/PD analysis, cumulative fraction responses obtained after Monte Carlo simulation for AUC/MIC > 30, 50 125 72.93%, 72.34% 30.86% E. coli 89.29%, 88.89% 58.57% Mycoplasma synoviae, respectively. Cumulative Cmax/MIC index 33.93% 40.18% M. administration 10 mg/kg could be appropriate treat infectious diseases caused gram-positive bacteria with lower than 1 µg/mL; however, although slow elimination vultures, plasma insufficient reach gram-negative stablished breakpoints.

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ژورنال

عنوان ژورنال: Antibiotics

سال: 2021

ISSN: ['2079-6382']

DOI: https://doi.org/10.3390/antibiotics10080957